🦠 Colonization vs. Infection
Feature | Colonization | Infection |
Definition | Microorganisms are present on or in the body but not causing harm. | Microorganisms invade tissues, multiply, and cause damage or symptoms. |
Immune Response | No immune reaction or tissue damage. | Active immune response → inflammation, pus, fever, pain. |
Symptoms | None (asymptomatic). | Present — fever, redness, swelling, drainage, pain. |
Contagious? | Can still spread to others even without symptoms. | Often contagious depending on organism and infection site. |
Example | MRSA on skin or in nose without illness. | MRSA wound infection causing redness and drainage. |
🧠 Quick Tip:
“Colonization = germs living there 🏠 — no problem yet.”“Infection = germs attacking ⚔️ — body fights back.”
🦠 Chain of Infection (Must Know!)
- Infectious Agent
- Reservoir
- Portal of Exit
- Mode of Transmission
- Portal of Entry
- Susceptible Host
🧠 Breaking any link prevents infection.
🦠 Types of exudate (Must Know!)
- Serous: Clear, thin, and watery fluid that is typically seen in the early stages of healing.
- Sanguineous: Bright red fluid that is mainly composed of blood.
- Serosanguineous: Pink or reddish fluid that contains a small amount of blood.
- Purulent: Formation of Pus. Thick, yellow, green, or white fluid that contains pus, which is a mixture of dead white blood cells, bacteria, and debris.
- Mixed: A combination of different types of exudate.
🩸 Modes of Transmission
Type | Example Diseases | PPE/Precautions |
Contact | MRSA, C. difficile | Gloves, gown |
Droplet | Influenza, meningitis | Mask, gloves |
Airborne | TB, measles, COVID | N95 respirator, negative-pressure room |
Indirect | Contaminated surfaces or instruments | Hand hygiene + disinfection |
🧍 Inflammation & Defense
- Signs: redness, heat, swelling, pain, loss of function.
- Learn Table 28.2 (body defenses).
- Stages of infection:
- Incubation – pathogen enters, no symptoms.
- Prodromal – mild, vague symptoms. nonspecific signs and symptoms and patient may be capable of spreading disease to others
- Illness – severe symptoms. signs and symptoms specific to type of infection
- Convalescence – recovery phase.
🏥 Health-Care–Associated Infections (HAIs)
- Caused by poor asepsis or cross-contamination.
- Nosocomial diseases = healthcare-associated infections (HAIs)
- High-risk patients: elderly, malnourished, immunocompromised, post-surgery.
- Common sources: catheters, suction, BP cuffs, uncleaned equipment.
- Always use dedicated equipment for isolation patients.
🏥 Health Care–Associated Infections (HAIs)
Type | Source | Example |
Iatrogenic | From a procedure | Catheter-associated UTI |
Exogenous | From outside microorganisms | MRSA, Salmonella |
Endogenous | From altered patient flora | Yeast infection after antibiotics |
🧠 Prevention: Hand hygiene, aseptic technique, clean or single-patient equipment.
💊 Antibiotics
- Overuse can weaken immune defenses or cause resistance.
- Monitor for superinfection (e.g., yeast infection after antibiotics).
🩹 Asepsis & Cleaning
- Medical asepsis: “clean technique.”
- Surgical asepsis: “sterile technique.” Used for invasive procedures and open wounds.
- Pouring liquids: Avoid splashing; keep sterile field dry.
- Clean from clean → dirty areas.
- Use PPE appropriate to the situation.
- Disinfect with bleach, alcohol wipes, or CaviWipes.
😷 Cough Etiquette
- Cover mouth/nose with tissue or elbow when coughing.
- Dispose of tissue and perform hand hygiene immediately.
- Wear a mask if coughing near others.
- Keep 3 feet (1 meter) distance from others if symptomatic.
🧍♀️ Patient Communication & Education
- Introduce yourself when wearing a mask (patients can’t see your face).
- Teach patients about handwashing, vaccination, and infection prevention.
- Include travel history in assessment for infectious diseases.
📋 Nursing Process for Infection
- Diagnosis examples:
- Risk for Infection
- Impaired Tissue Integrity
- Social Isolation
- Goals (SMART): control infection spread, reduce symptoms, verbalize prevention methods.
- Team approach: nurses, providers, infection control, and patient/family.
🧫 Infection Control & Surgical Asepsis — Study Guide
🦠 Communicable Diseases
- Communicable disease: Infection transmitted from one person to another.
- Symptomatic: Clinical signs and symptoms are present.
- Asymptomatic: No signs or symptoms, but infection can still spread.
🧠 Example: COVID-19 and hepatitis B can both be asymptomatic yet contagious.
🧍 Body’s Cellular Response to Infection or Injury
- Vascular & Cellular Response: Blood vessels dilate → ↑ blood flow → redness, heat, swelling.
- Inflammatory Exudate: Fluid, pus, or drainage containing WBCs and debris collects at injury site.
- Tissue Repair: Damaged tissue replaced with new cells (regeneration or scar formation).
🧠 Goal: Contain infection and promote healing.
🩺 Nursing Diagnoses Related to Infection
- Risk for Infection
- Imbalanced Nutrition: Less Than Body Requirements
- Impaired Oral Mucous Membrane
- Risk for Impaired Skin Integrity
- Social Isolation
- Impaired Tissue Integrity
- Readiness for Enhanced Immunization Status
🧠 Plan goals that reduce exposure, control infection spread, and support immune function.
🧴 Disinfection vs. Sterilization
Process | Purpose | Kills Spores? | Examples |
Disinfection | Eliminates many or all microorganisms (not spores) from inanimate objects | ❌ | Alcohol, bleach, CaviWipes |
High-Level Disinfection | For critical equipment (e.g., endoscopes) | ⚠️ Some | Glutaraldehyde, hydrogen peroxide |
Sterilization | Destroys all microorganisms including spores | ✅ | Steam autoclave, ethylene oxide gas |
🧠 Always sterilize instruments that enter sterile body areas.
🩹 Surgical Asepsis (Sterile Technique)
Purpose
- Prevents contamination of open wounds.
- Isolates the operative area from unsterile environments.
- Maintains a sterile field for invasive procedures.
🧠 Used in: surgery, catheter insertion, sterile dressing changes, suctioning lower airway.
🧾 Sterile Field
- A clean, prepared area free of microorganisms to receive sterile items.
⚖️ Principles of Surgical Asepsis
- A sterile object remains sterile only when touched by another sterile object.
- Only sterile items go on a sterile field.
- Anything below waist level or out of sight is contaminated.
- Prolonged air exposure contaminates a sterile field.
- Moisture contaminates by capillary action (keep surfaces dry).
- Fluids flow downward — hold hands above elbows when scrubbing.
- Edges (1 inch) of a sterile field are considered contaminated.
🧠 Tip: If in doubt, consider it contaminated and replace it.